Endocrine Abstracts

Treatment of acromegalic patients with somatostatin analogues decreases hGH and IGF1 concentrations, improves general and metabolic conditions and decreases morbidity and mortality in these patients. We assessed the efficacy of octreotide LAR (SSLAR) in treating acromegalic patients following non-radical surgery of pituitary adenoma at a single centre.Materials and methods: At our Centre we follow 85 acromegalic patients who underwent surgery, including ...

Introduction: The relation of hypothyroidism with the breast cancer is described early in the literature based in some common pathophysiological paths which associate thyroid gland and breast tissue.Methods: A literature research in PubMed and Cochrane library database was performed for articles studying any possible association between the risk for development of breast cancer with the presence of hypothyroidism history in women.R...

Objective: To audit GH deficiency in the transition service at our institution.Methods: Patients between 19–25 years old were identified from the database of patients having GH replacement. Data were obtained from case notes and electronic records.Results: Twenty-four patients in the transition service were identified to be GH deficient, 13 female and 11 male. 14/24 had CNS or pituitary tumours treated in childhood, 11 having ...

The authors studied the effect of one year of therapy with rhGH on growth velocity in patients with growth hormone deficiency (GHD). We analyzed 120 patients (85 boys and 35 girls), 6–21.5 years of age (mean 14.2±3.0) treated in Department of Endocrinology and Diabetology for Children and Adolescents, Medical University of Wrocław. Patients received rhGH in a dose of 0.7IU/Kg/week. Partial GHD was diagnosed in 71 cases (52 boys and 19 girls), complete GHD was ...

Although improvements in obstetric and neonatal care in recent years have led to reduction in morbidity and mortality from pre-eclampsia, our ability to predict the condition has not improved significantly. Endothelial dysfunction underlies many of the manifestations of pre-eclampsia. In this study we will assess methods of detecting endothelial dysfunction and arterial stiffness in high-risk pregnant women in early and late pregnancy. Sixty women with 2 or more risk fa...

The adrenal incidentalomas have become a common clinical problem. In the vast majority of cases these masses are non- secreting adrenocrotical adenomas. However, some may show minor endocrine abnormalities with a subclinical hyperfunction or represent malignancies.Objectives: The aim of the study was to analyze and follow-up of incidentalomas and to establish the risk factors for mass enlargement and/or hormonal disturbances.Materi...

Poland syndrome (PS) is a defect consisting in unilateral deficiency of the pectoralis major muscle and anomaly of the ipsilateral upper limb, usually in the form of syndactyly or synbrachydactyly. The absence of a nipple and the aplasia of a mammary gland are frequently found. The incidence of PS ranges from 1:7000 to 1:100 000.The authors present a 5-year-old girl with a very rare coincidence of PS and Turner syndrome. The child was born after 38 weeks...

Thyroid disease is associated with atherosclerosis cardiovascular disease. This is undoubted for overt hypothyroidism, but is controversy in subclinical hypothyroidism hittle is known about the relationship between insulin resistance and thyroid function. It is well known that insulin resistance is the main part of metabolic syndrome. We aimed to investigate the relationship between thyroid function, body mass index (BMI) and homeostasis model assessment index for insulin resi...

Subclinical hypothyroidism (SH) is very frequent condition in older population. If can occur in 12–20% of patients older than 60. It is well known today that thyroid hormones can increase gene expression of APO-B receptors in the liver and by this way improve catabolism of atherogenic lipoproteins. They also can regulate processes of contractility and weakening of heart muscle. Decrease of cardiac output and diastolic disfunction of left ventricle can be revealed in SH pa...

A 12-year-old girl presented with dizziness, palpitations, headaches and sweating associated with hypertension (170/100 mmHg) and tachycardia (180 beats per minute). Repeated urinary and serum catecholamines were initially unremarkable. Routine biochemical and haematological testing was normal as were serum gut peptides. The patient was commenced on phenoxybenzamine, nifedipine and propranolol. This improved her symptoms, and corrected her tachycardia and raised blood pressure...